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KMID : 1059520070510040352
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Journal of the Korean Chemical Society
2007 Volume.51 No. 4 p.352 ~ p.355
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3,7-Dihydroxy-2,4,6-trimethoxyphenanthrene, A New Phenanthrene from Bulbophyllum Odoratissimum
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Chen Ye-Gao
Xu Jun-Ju
Yu Hong
Qing Chen
Zhang Yan-Li
Liu Ying
Wang Ji-Hua
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Abstract
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A new phenanthrene derivative 3,7-dihydroxy-2,4,6-trimethoxyphenanthrene was isolated from the all plant of Bulbophyllum odoratissimum, and its structure was elucidated by extensive spectral studies and chemical transformation. The compound displayed cytotoxicity against the growth of human leukemia cell lines K562 and HL-60, human lung adenocarcinoma A549, human hepatoma BEL-7402 and human stomach cancer cell lines SGC-7901 with IC50 values of 14.23, 10.02, 3.42, 15.36 and 1.13 mg/ml respectively.
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KEYWORD
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Bulbophyllum odoratissimum, Orchidaceae, Phenanthrene, 3, 7-Dihydroxy-2, 4, 6-trimethoxyphenanthrene, Cytotoxicity
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